Methodists paid attention (in contrast to the Dogmatists and Empiricists) to the disease alone as opposed to the situation of the individual patient, i.e., his medical history and personal situation. The disease alone dictates treatment (K

One of the most influential aspects of Galenic practice was his implementation of (or invention of-as per Wesley Smith) the Hippocratic theory of the four humours (phlegm, blood, black bile, and yellow bile). These points of focus relate to a theory of health as balance. Each of these four humours is related to the three principal points of the body: head (phlegm), heart (blood), black bile (liver) and yellow bile (the liver's complement, the gall bladder). The three principal points of the body are also loosely linked to the Platonic tripartite soul: head (sophia, reason), heart (thumos, emotion or spiritedness), liver (epithumos, desire). Thus, the sort of just balance of the soul that Plato argues for in the Republic is also the ground of natural health. When one part of the soul/body is out of balance, then the individual becomes ill. The physician's job is to assist the patient in maintaining balance. If a person is too full of uncontrollable emotion or spiritedness, for example, then he is suffering from too much blood. The obvious answer is to engage in bloodletting (guaranteed to calm a person down). As in the case of pharmacology and the contraries, the four humours provide a comprehensive account of what it means to obtain and maintain health via the balancing of various primary principles.

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